Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
M. Simon, M. van Meter, J. Ablaeva, Z. Ke, R. S. Gonzalez, T. Taguchi, M. De Cecco, K. I. Leonova, V. Kogan, S. L. Helfand, N. Neretti, A. Roichman, H. Y. Cohen, M. Antoch, A. Gudkov, , V. Gorbunova
This study shows that inhibiting L1 retrotransposition with NRTIs improves health and extends the lifespan of SIRT6 knockout mice by reducing type I interferon response and DNA damage.
bioRxiv · Nov 4, 2018 · PreprintMolecular Biology