Author

J. Ablaeva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:multiple species· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Seluanov· 3 shared J. Y. Lu· 3 shared V. Gorbunova· 3 shared Z. Zhang· 3 shared D. Firsanov· 2 shared E. Hillpot· 2 shared F. T. Zakusilo· 2 shared S. A. Biashad· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersEvolutionary Biology

A. Seluanov

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

Y. Zhao, Z. Zheng, Z. Zhang, E. Hillpot, Y. S. Lin, F. T. Zakusilo, J. Y. Lu, J. Ablaeva, R. A. Miller, E. Nevo, A. Seluanov, V. Gorbunova

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

bioRxiv · May 8, 2023Evolutionary Biology

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

D. Firsanov, M. Zacher, X. Tian, Y. Zhao, T. L. Sformo, G. Tombline, S. A. Biashad, A. Gilman, N. Hamilton, A. Patel, M. Straight, M. Lee, J. Y. Lu, E. Haseljic, A. Williams, , Gladyshev

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

bioRxiv · May 7, 2023 · PreprintCancer Biology

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

Z. Zhang, X. Tian, J. Y. Lu, K. Boit, J. Ablaeva, F. T. Zakusilo, S. Emmrich, D. Firsanov, E. Rydkina, S. A. Biashad, Q. Lu, A. Tyshkovskiy, V. N. Gladyshev, S. Horvath, A. Seluanov, V. Gorbunova

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

bioRxiv · May 4, 2023 · PreprintPhysiology

Epigenetic predictors of maximum lifespan and other life history traits in mammals

C. Z. Li, A. Haghani, T. R. Robeck, D. Villar, A. T. Lu, J. Zhang, C. G. Faulkes, H. Vu, J. Ablaeva, D. M. Adams, R. Ardehali, A. Arneson, C. S. Baker, K. Belov, D. T. Blumstein, , A. J. Jasinska

The paper develops methylation-based models to predict maximum lifespan and other life history traits in mammals using data from 12,000 samples across 192 species.

bioRxiv · May 16, 2021 · PreprintEvolutionary Biology

Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice

M. Simon, M. van Meter, J. Ablaeva, Z. Ke, R. S. Gonzalez, T. Taguchi, M. De Cecco, K. I. Leonova, V. Kogan, S. L. Helfand, N. Neretti, A. Roichman, H. Y. Cohen, M. Antoch, A. Gudkov, , V. Gorbunova

This study shows that inhibiting L1 retrotransposition with NRTIs improves health and extends the lifespan of SIRT6 knockout mice by reducing type I interferon response and DNA damage.

bioRxiv · Nov 4, 2018 · PreprintMolecular Biology