J. M. Sedivy

TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

This study investigates how senescent fibroblasts influence tumor growth and immune response, showing that targeting the p21-driven SASP and combining senolytics with cancer therapies can suppress tumor growth.

Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

This study identifies and characterizes small molecule inhibitors of the LINE-1 retrotransposon endonuclease, showing they reduce DNA damage and inflammation in senescent cells.

Integrative analyses uncover mechanisms by which aging drives B cell lymphoma

This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

This paper shows that the N-terminus and coiled-coil domain of ORF1 protein mediate phase separation, which may protect L1 transcripts from degradation.

Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice

This study shows that inhibiting L1 retrotransposition with NRTIs improves health and extends the lifespan of SIRT6 knockout mice by reducing type I interferon response and DNA damage.