V. Gorbunova

Hyaluronidase inhibitor delphinidin inhibits cancer metastasis

This study identifies delphinidin as a hyaluronidase inhibitor that reduces cancer metastasis in cell cultures and mouse models.

Limited Cell-Autonomous Anticancer Mechanisms in Long-Lived Bats

This study shows that bat fibroblasts require fewer oncogenic hits for malignant transformation compared to other long-lived mammals, suggesting reliance on non-cell autonomous tumor suppression mechanisms.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

Epigenetic predictors of species maximum lifespan and other life history traits in mammals

The paper develops DNA methylation predictors for mammalian maximum lifespan, gestation time, and sexual maturity, showing species-level epigenetic signatures that differ from individual lifespan variation.

Proteome birthdating reveals age-selectivity of protein ubiquitination

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging.

The paper uses partial cellular reprogramming to reduce DNA damage in an ERCC1 mouse model of premature aging, showing restoration of the epigenetic clock and DNA repair processes.

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

Accurate proteome-wide measurement of methionine oxidation in aging mouse brains

This study introduces a method to measure methionine oxidation in mouse brains and finds that oxidation is consistent across individuals but not significantly altered with age.

Naked mole-rat hematopoietic stem and progenitors are highly quiescent with an inherent myeloid bias

This study identifies unique hematopoietic features in naked mole-rats, including myeloid bias and quiescent stem cells, linked to their exceptional longevity.

Ectopic cervical thymi and no thymic involution until midlife in naked mole-rats

This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.

DNA Methylation Networks Underlying Mammalian Traits

This study analyzes DNA methylation across 11,117 samples from 176 species to identify modules related to traits like age, lifespan, and phylogeny, revealing epigenetic patterns across evolution and aging.

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

The hematopoietic landscape at single-cell resolution reveals unexpected stem cell features in naked mole-rats

This study profiles the hematopoietic system of naked mole-rats at single-cell resolution, revealing unique stem cell features associated with longevity and cancer resistance.

Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice

This study shows that inhibiting L1 retrotransposition with NRTIs improves health and extends the lifespan of SIRT6 knockout mice by reducing type I interferon response and DNA damage.