Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors
J. S. Gallego-Murillo, G. Iacono, L. A. M. van der Wielen, E. van den Akker, M. von Lindern, S. A. Wahl
This study scales up erythroblast culture to bioreactors, identifies optimal conditions for proliferation and differentiation, and achieves transfusion-ready cRBCs.
bioRxiv · Feb 11, 2022Bioengineering