Author

E. van den Akker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

J. S. Gallego-Murillo· 3 shared F. Aglialoro· 2 shared G. Iacono· 2 shared M. M. von Lindern· 2 shared M. von Lindern· 2 shared A. Abay· 1 shared A. Abeijon-Valle· 1 shared A. F. Svendsen· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

J. S. Gallego-Murillo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Differentiating erythroblasts adapt to turbulent flow by accelerating maturation and activating cholesterol biosynthesis.

G. Iacono, A. Abay, J. S. Gallego-Murillo, F. Aglialoro, N. Yagci, K. Fu, A. F. Svendsen, M. M. von Lindern, E. van den Akker

This study shows that erythroblasts adapt to shear stress by accelerating maturation and upregulating cholesterol biosynthesis, enhancing osmotic resistance and enucleation.

bioRxiv · Dec 8, 2023 · PreprintCell Biology

Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors

J. S. Gallego-Murillo, G. Iacono, L. A. M. van der Wielen, E. van den Akker, M. von Lindern, S. A. Wahl

This study scales up erythroblast culture to bioreactors, identifies optimal conditions for proliferation and differentiation, and achieves transfusion-ready cRBCs.

bioRxiv · Feb 11, 2022Bioengineering

Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells in the absence of transferrin

J. S. Gallego-Murillo, N. Yagcı, E. M. Pinho, A. Abeijon-Valle, A. Wahl, E. van den Akker, M. von Lindern

This study shows that iron-loaded deferiprone can replace holotransferrin in erythroid cultures, supporting reticulocyte differentiation and erythroblast expansion.

bioRxiv · Aug 2, 2021 · PreprintCell Biology

Mouse Classical and Non-Classical Monocytes Express Comparable Levels of Chemokine Receptor CX3CR1

L. Cassetta, E. Heideveld, G. Matilionyte, S. Fragkogianni, E. Van den akker, N. Kippen, T. Kitamura, J. W. Pollard

This study shows that Cx3cr1 mRNA expression differs between circulating monocytic subsets in humans but not in mice.

bioRxiv · Apr 10, 2020 · PreprintImmunology

CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

G. Yi, A. Mandoli, L. Jussen, E. Tijchon, G. Cordonnier, M. Hansen, B. Kim, L. N. Nguyen, P. Jansen, M. Vermeulen, E. van den Akker, J. Bond, J. H. A. Martens

This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.

bioRxiv · Oct 29, 2018Cancer Biology

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

B. P. Nicolet, S. Engels, F. Aglialoro, E. van den Akker, M. M. von Lindern, M. C. Wolkers

The paper analyzes circRNA expression in human hematopoietic cells, finding cell-type specific patterns and increased expression during maturation.

bioRxiv · Apr 12, 2018Immunology