Author

M. W. Ledeboer

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

D. Quentin· 1 shared D. Vinayagam· 1 shared F. Merino· 1 shared G. Malojcic· 1 shared M. Stabrin· 1 shared M. Yu· 1 shared O. Hofnagel· 1 shared O. Sitsel· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

D. Quentin

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1 paper

Recent·Most cited

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

D. Vinayagam, D. Quentin, O. Sitsel, F. Merino, M. Stabrin, O. Hofnagel, M. Yu, M. W. Ledeboer, G. Malojcic, S. Raunser

The paper reports structures of TRPC4 in complex with inhibitors, activators, and calmodulin, revealing how ligand binding and calmodulin interaction regulate the channel's conformation.

bioRxiv · Jun 30, 2020Biochemistry