F. Merino

A computational model for lipid-anchored polysaccharide export by the outer-membrane protein GfcD

This paper presents a computational model of GfcD, an outer-membrane β-barrel protein, showing it facilitates lipid-anchored polysaccharide export through a lateral aperture.

Transient structural properties of the Rho GDP-dissociation inhibitor

This study reveals that the N-terminus of RhoGDI1 has preformed structural features in its free form, challenging the disorder-to-order transition model of GTPase inactivation.

The bigger picture: global analysis of solubilization performance of classical detergents versus new synthetic polymers utilizing shotgun proteomics

This study compares the solubilization performance of synthetic polymers and detergents using shotgun proteomics to extract membrane proteins in native nanodiscs.

Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores

The paper reports the structure of the RZZ complex and demonstrates the molecular mechanism of corona assembly at human kinetochores using cryo-EM and in vitro assays.

Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens

The paper investigates how actin interacts with nucleotidyl cyclase toxins from bacterial pathogens to activate them, revealing structural changes and allosteric mechanisms.

A structure-derived mechanism reveals how capping protein promotes nucleation in branched actin networks

This study reveals how capping protein (CP) promotes nucleation in branched actin networks by controlling access to terminal actin subunits and inhibiting nucleation promoting factors.

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

The paper reports structures of TRPC4 in complex with inhibitors, activators, and calmodulin, revealing how ligand binding and calmodulin interaction regulate the channel's conformation.

Structural effects and functional implications of phalloidin and jasplakinolide binding to actin filaments

This study examines how phalloidin and jasplakinolide affect actin filament structure and function by stabilizing different states during actin dynamics.

Profilin and formin constitute a pacemaker system for robust actin filament growth

This study shows that profilin and formin work together to control actin filament growth rates, making them resilient to changes in soluble actin concentrations.

SPHIRE-crYOLO: A fast and accurate fully automated particle picker for cryo-EM

The paper introduces crYOLO, a deep learning-based particle picker for cryo-EM that achieves high accuracy and speed, enabling automated data pre-processing.

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

The paper reports the cryo-EM structure of zebrafish TRPC4 in its closed, unliganded state, revealing key structural features and insights into its function and pharmacology.