D. Vinayagam

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

The paper reports structures of TRPC4 in complex with inhibitors, activators, and calmodulin, revealing how ligand binding and calmodulin interaction regulate the channel's conformation.

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

The paper reports the cryo-EM structure of zebrafish TRPC4 in its closed, unliganded state, revealing key structural features and insights into its function and pharmacology.