PARP activity is essential for retinal photoreceptor survival in the human homologous RhoI255del mouse model for autosomal dominant retinitis pigmentosa
Yu Zhu, Azdah Hamed A Fallatah, Kangwei Jiao, M. W. Seeliger, François Paquet‐Durand
This study shows that PARP inhibitors cause rod photoreceptor toxicity in a dominant RP mouse model, unlike in recessive RP, and highlights the need for careful use of these drugs in RP treatment.
bioRxiv · Aug 21, 2025 · PreprintNeuroscience