Kangwei Jiao

This study investigates how PARP regulates calpain activity in rd1 mouse photoreceptors and identifies potential therapeutic targets for inherited retinal degenerations.

This study investigates the role of PPARs and PGC-1α in photoreceptor neuroprotection in rd1 mouse model of retinal degeneration, finding that their activation reduces photoreceptor death and PARP activity.

This study identifies Esr1 activation as a protective mechanism against neuroinflammation in retinal degeneration, showing it suppresses Tnf-α signaling and reduces photoreceptor death.

This study shows that PARP inhibitors cause rod photoreceptor toxicity in a dominant RP mouse model, unlike in recessive RP, and highlights the need for careful use of these drugs in RP treatment.

This study investigates the effects of cGMP analogues targeting PKG on photoreceptor viability and function in a mouse model of autosomal dominant retinitis pigmentosa, finding neuroprotection and preserved retinal function.

This study evaluates the effects of HDAC inhibitors in an ADRP mouse model, finding that different inhibitors affect rod and cone photoreceptors variably, with MPT0G211 showing strong protection and ACY-957 causing cell death and proliferation.

This study investigates the role of calcium signaling in photoreceptor cell death in IRD using mouse models and identifies calpain-2 as a key contributor to degeneration.

This study uses scRNA-seq to analyze metabolic changes in mouse retinal cells during degeneration, identifying Ca2+-signaling and MAPK pathway involvement.