Yu Zhu

This study shows that PARP inhibitors cause rod photoreceptor toxicity in a dominant RP mouse model, unlike in recessive RP, and highlights the need for careful use of these drugs in RP treatment.

This study investigates the effects of cGMP analogues targeting PKG on photoreceptor viability and function in a mouse model of autosomal dominant retinitis pigmentosa, finding neuroprotection and preserved retinal function.

This study evaluates the effects of HDAC inhibitors in an ADRP mouse model, finding that different inhibitors affect rod and cone photoreceptors variably, with MPT0G211 showing strong protection and ACY-957 causing cell death and proliferation.

This paper introduces a novel mouse model of dominant retinitis pigmentosa caused by the RHO{Delta}I255 mutation, showing rapid photoreceptor degeneration, neuroinflammation, and disrupted neuronal connectivity.

The paper demonstrates that calpain activity can be detected in live retinal tissue as a biomarker for retinal degeneration, showing distinct temporal activity patterns of calpain isoforms during photoreceptor cell death.