Pharmacology & ToxicologybioRxiv
Functional Evidence for Biased Inhibition of G protein Signaling by YM-254890 in Human Coronary Artery Endothelial Cells
Q. Peng, S. Alqahtani, M. Z. A. Nasrullah, J. Shen
This study evaluates YM-254890's functional selectivity as a G protein inhibitor in human coronary artery endothelial cells, finding it inhibits both Gq and Gs proteins but not Gi/o.
DOI 10.1016/j.ejphar.2020.173706