Strain-dependent impact of G and SH deletions provide new insights for live-attenuated HMPV vaccine development
J. Dubois, A. Pizzorno, M.-H. Cavanagh, B. Padey, C. Nicolas de Lamballerie, O. Uyar, M.-C. Venable, J. Carbonneau, A. Traversier, T. Julien, C. Couture, B. Lina, M.-E. Hamelin, O. Terrier, M. Rosa-Calatrava, G. Boivin
This study evaluates strain-dependent effects of G and SH deletions in HMPV to inform live-attenuated vaccine development, finding that SH-deleted A1/C-85473 virus is attenuated and protective in mice.
bioRxiv · Sep 25, 2019Microbiology