Author

M.-F. Langelier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. M. Pascal· 3 shared A. Rasti· 1 shared A. Sverzhinsky· 1 shared A. Throup· 1 shared B. D. G. Page· 1 shared B. E. Black· 1 shared D. Rehling· 1 shared G. Benzi· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

J. M. Pascal

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Author profile →

3 papers

Recent·Most cited

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

M.-F. Langelier, X. Lin, S. Zha, J. M. Pascal

This study shows clinical PARP inhibitors can allosterically retain PARP2 on DNA breaks, differing from their effect on PARP1, with implications for PARPi toxicity and design.

bioRxiv · Nov 8, 2022Biochemistry

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

N. C. K. Valerie, K. Sanjiv, O. Mortusewicz, S. M. Zhang, S. Alam, M. J. Pires, H. Stigsdotter, A. Rasti, M.-F. Langelier, D. Rehling, A. Throup, M. Desroses, J. Onireti, P. Wakchaure, I. Almlof, , M. Altun

CeTEAM evaluates drug-target interactions and phenotypic responses using biosensors, revealing how drug binding affects cellular activities and metabolism.

bioRxiv · Sep 19, 2022Biochemistry

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADPribose modifications

M.-F. Langelier, R. Billur, A. Sverzhinsky, B. E. Black, J. M. Pascal

This study shows HPF1 regulates PARP1/2 to balance initiation and elongation of ADP-ribose modifications, ensuring efficient serine modification during DNA damage response.

bioRxiv · May 19, 2021Biochemistry