Author

S. M. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

S. G. Rudd· 3 shared T. Helleday· 2 shared A. D. Balgi· 1 shared A. Rasti· 1 shared A. Throup· 1 shared A.-S. Jemth· 1 shared B. D. G. Page· 1 shared C. A. N. Gerak· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

S. G. Rudd

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

S. M. Zhang, C. B. Paulin, M. Michel, P. Marttila, M. Yagüe-Capilla, H. C. Bwanika, H. Shu, R. Papagudi Vekatram, E. Wiita, A.-S. Jemth, I. Almlöf, O. Loseva, F. Ortis, C. Dirks, T. Koolmeister, , S. G. Rudd

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

bioRxiv · Jan 17, 2023 · PreprintBiochemistry

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

N. C. K. Valerie, K. Sanjiv, O. Mortusewicz, S. M. Zhang, S. Alam, M. J. Pires, H. Stigsdotter, A. Rasti, M.-F. Langelier, D. Rehling, A. Throup, M. Desroses, J. Onireti, P. Wakchaure, I. Almlof, , M. Altun

CeTEAM evaluates drug-target interactions and phenotypic responses using biosensors, revealing how drug binding affects cellular activities and metabolism.

bioRxiv · Sep 19, 2022Biochemistry

Drug synergy scoring using minimal dose response matrices

P. Mäkelä, S. M. Zhang, S. G. Rudd

This paper optimizes drug synergy scoring by determining the minimal dose response matrix size needed to robustly detect and quantify synergy between two drugs.

BMC Research Notes · Jan 19, 2021Peer-reviewedPharmacology & Toxicology

A Multi-pronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

C. A. N. Gerak, S. M. Zhang, A. D. Balgi, I. J. Sadowski, R. B. Sessions, L. P. McIntosh, M. Roberge

This study develops experimental and computational assays to identify small molecule inhibitors of ETV6 PNT domain polymerization, finding no direct binders but gaining insights for future therapeutic development.

bioRxiv · Aug 20, 2020Biochemistry

SAMHD1 promotes oncogene-induced replication stress

S. M. Zhang, J. M. Calderon-Montano, S. G. Rudd

This study identifies SAMHD1 as a tumor suppressor that promotes replication stress in oncogene-driven cells by slowing DNA replication fork speeds and reducing cell proliferation.

bioRxiv · Jul 29, 2020 · PreprintCancer Biology