GPR41/43 regulates blood pressure by improving gut epithelial barrier integrity to prevent TLR4 activation and renal inflammation
R. R Muralitharan, T. Zheng, E. Dinakis, L. Xie, A. Barboro-Wahl, H. Jama, M. Nakai, M. Paterson, C. Johnson, E. Salimova, N. Bittto, M.-K. Liaskos, D. M. Kaye, J. O'Donnell, C. R. Mackay, F. Z. Marques
This study shows that GPR41/43 receptors regulate blood pressure by maintaining gut barrier integrity and preventing renal inflammation through TLR4 signaling.
bioRxiv · Mar 20, 2023Physiology