A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression
J. Zhang, C. Yan, J. Xiong, Z. Zhou, Q. Li, C. Gao, M. Zhang, L. Yu, J. Li, M.-M. Hu, C.-S. Zhang, C. Cai, H. Zhang
This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.
bioRxiv · Feb 17, 2023Cell Biology