C. Yan

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.

Machine Learning Models for Cardiovascular Disease Prediction: A Comparative Study

This study compares KNN, logistic regression, and random forest for predicting cardiovascular disease using a Kaggle dataset, finding random forest to be the most accurate.

High-Throughput Phenotyping of Seed Quality Traits Using Imaging and Deep Learning in Dry Pea

This paper develops an automated seed quality assessment tool for dry peas using imaging and deep learning, achieving high accuracy and efficiency compared to traditional methods.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

The EGF/EGFR-YAP1/TEAD2 axis-mediated BRAF inhibitor vemurafenib resistance upregulates STIM1 in melanoma

This study identifies the EGF/EGFR-YAP1/TEAD2 axis as a mechanism by which vemurafenib resistance upregulates STIM1 in melanoma.

The role of neutrophil typing in homeostatic resilience protective model of inflammatory preconditioning

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein

This study investigates the biophysical mechanism of allosteric regulation of actin capping protein using single-molecule FRET and MD simulations, revealing conformational changes linked to ligand binding.

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis

This study identifies FAM210A as a regulator of mitochondrial translation and cardiac mitochondrial homeostasis, showing its deficiency leads to heart failure and its overexpression rescues cardiac function in ischemic heart disease.

The genomic landscape of adaptation to a new host plant

This study identifies a large genomic inversion associated with host adaptation in Tephritis conura flies, showing its role in reproductive isolation and speciation.

Cell-type specific EWAS identifies genes involved in HIV pathogenesis andoncogenesis among people with chronic HIV infection

The paper identifies cell-type specific CpG methylation changes in HIV-infected individuals linked to immune function and cancer pathways.

CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth

This study shows that CXCR2 expression in melanoma progenitor cells drives tumor growth by altering transcriptional programs and immune responses.

RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm

This study identifies miR-193a-5p as a regulator of vascular smooth muscle cell proliferation and migration in aortic aneurysms, showing that RelB represses its expression.

A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

Genome-wide analysis of anterior-posterior mRNA regionalization in Stentor coeruleus reveals a role for the microtubule cytoskeleton

The paper identifies anterior-posterior mRNA regionalization in Stentor coeruleus and shows microtubules are involved in maintaining this distribution through RNAi experiments.

Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis

This study shows that 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis in models of acute lung injury and sepsis.

Proteomic Dissection of a Giant Cell

The paper quantifies polarized protein localization in Stentor coeruleus by cutting cells along the anterior-posterior axis and analyzing proteomic enrichment, finding 30% of proteins show polarized localization.

Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

The framework of plant regeneration in duckweed (Lemna turonifera) comprises genetic transcript regulation and cyclohexane release

This study identifies genetic transcript regulation and cyclohexane release as factors enhancing duckweed regeneration through callus formation.

Modular, Cascade-like Transcriptional Program of Regeneration in Stentor

This study uses RNAseq to analyze transcriptional changes during regeneration in Stentor coeruleus, identifying distinct gene expression modules and a cascade mechanism involving translation products of early-expressed genes.

A deep generative model of 3D single-cell organization

The paper introduces a deep generative model to integrate 3D single-cell fluorescent image data of subcellular structures, enabling structure imputation and quantification of spatial variation.

Detection of pigeon circoviruses in ticks of sheep and camels in Inner Mongolia, China

The paper detects pigeon circovirus in ticks collected from sheep and camels in Inner Mongolia using high-throughput sequencing and PCR, revealing its genomic sequence and phylogenetic classification.

Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China

This study identifies new CCHFV strains in Inner Mongolia, China, showing genetic similarities to strains from Xinjiang and South Africa, suggesting long-term prevalence in the region.

Structural basis for sterol sensing by Scap and Insig

This study determines the structure of the Scap/Insig-2 complex in the absence of 25HC, revealing structural insights into cholesterol sensing and regulatory mechanisms.

Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating PPARγ-UCP2 cascade

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

Diet Potentially Drives the Differentiation of Eating Behaviours via Alterations to the Gut Microbiome in Infants

The paper investigates how infant formula diets alter gut microbiome composition and short-chain fatty acid production, which may reduce food responsiveness and contribute to eating behaviors linked to obesity.

A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

The paper analyzes gene expression changes in hiPSC-derived cardiomyocytes using single-cell RNA-seq, identifying key genes that mark differentiation stages and sources of variation across protocols and cell lines.

Undersampling correction methods to control γ-dependence for comparing β-diversity between regions

This study evaluates undersampling correction methods for β-diversity to reduce γ-dependence, finding that diversity accumulation curves outperform null models in removing γ-dependence.

Development of novel in vitro human alveolar epithelial cell models to study distal lung biology and disease

The paper develops novel immortalized human alveolar epithelial cell lines that can form organoids and exhibit lineage memory, offering a new in vitro model for distal lung biology and disease.

Automated hiPSC culture and sample preparation for 3D live cell microscopy

The paper describes an automated system for hiPSC culture and sample preparation to enable standardized 3D live cell imaging and analysis.