J. Xiong

Pressorum Sensing: Growth-induced Compression Activates cAMP Signaling in Pseudomonas aeruginosa

This paper introduces pressorum sensing in Pseudomonas aeruginosa, showing mechanical compression triggers cAMP signaling via the Pil-Chp system, leading to increased virulence.

PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease

This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Comparison and Evaluation of Neutralization of Clinically Frequently Used Antimicrobial Agents Using Three Different Culture Media in Simulated Blood Cultures

This study evaluates three blood culture media for antimicrobial neutralization, finding BACT/ALERT media outperformed others in recovery rates, while Thermo media had the lowest performance.

Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3

This study identifies METTL3-mediated stabilization of RRBP1 mRNA via m6A in prostate cancer and develops small-peptide inhibitors to target this pathway.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

Insm1 regulates the development of mTECs and immune tolerance

This study shows that Insm1 regulates mTEC development and immune tolerance by interacting with Aire and affecting gene expression.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

Hoxb5 reprograms murine multipotent blood progenitors into hematopoietic stem cell-like cells

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

Regeneration of humoral immunity from pluripotent stem cells by defined transcription factors

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

A novel MRI-based data fusion methodology for efficient, personalised, compliant simulations of aortic haemodynamics

This paper introduces an MRI-based data fusion method for simulating aortic haemodynamics, achieving accurate and efficient patient-specific compliant simulations without CT data.

Class II LBD genes ZmLBD5 and ZmLBD33 regulate gibberellin and abscisic acid biosynthesis

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

Trans-Golgi network-lipid droplet contacts maintain the TGN integrity and function via lipid transfer activities of VPS13B

This study identifies VPS13B as a mediator of TGN-LD membrane contact sites, showing its role in lipid transfer and TGN integrity through specific domains.

Human Embryonic Stem Cell-derived Lung Organoids: a Model for SARS-CoV-2 Infection and Drug Test

This study shows that human lung organoids can model SARS-CoV-2 infection and drug response, revealing virus targets and effective antiviral treatment.

Lateral mechanical impedance rather than frontal, promotes cortical expansion of roots

The paper shows that lateral mechanical impedance, not frontal, promotes cortical expansion and radial growth in maize roots.

A Pan-Cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling

This study profiles single cells from multiple cancer types to create a pan-cancer blueprint of stromal cell heterogeneity, identifying shared and unique cell populations and their characteristics.

Aging immune system-related blood cell DNA methylation can predict the onset of early stage colorectal cancer

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

Predominant Patterns of Splicing Evolution on Human, Chimpanzee, and Macaque Evolutionary Lineages

The paper analyzes splicing evolution across human, chimpanzee, and macaque lineages, finding that changes in exon inclusion frequency are more functionally relevant than constitutive-to-alternative transitions.

SPIN1 promotes tumorigenesis by blocking the uL18-MDM2-p53 pathway

This study identifies SPIN1 as a regulator of the uL18-MDM2-p53 pathway, showing that SPIN1 promotes tumorigenesis by inhibiting p53 activation.