IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.
Catherine M. Kerr, Macie A. Proctor-Roser, Srivatsan Parthasarathy, Joseph J. O’Connor, Jessica J. Pfannenstiel, Robin C. Orozco, Anthony R. Fehr
This study shows that IFN-γ is required for efficient replication of JHMV in mouse brains, despite reduced viral replication in IFN-γ and IFN-γR knockout mice.
PLoS ONE · Jun 5, 2025Peer-reviewedMicrobiology