Srivatsan Parthasarathy

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

This study shows that IFN-γ is required for efficient replication of JHMV in mouse brains, despite reduced viral replication in IFN-γ and IFN-γR knockout mice.

This study identifies pyrrolo-pyrimidine-based Mac1 inhibitors that inhibit MHV and SARS-CoV-2 replication, with some compounds showing IFN-dependent antiviral activity.

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.