Author

Joseph J. O’Connor

University of Kansas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Anthony R. FehriD· 3 shared Anuradha RoyiD· 2 shared Catherine M. KerriD· 2 shared Jessica J. PfannenstieliD· 2 shared Philip Gao· 2 shared Reem Khattabi· 2 shared Yousef M. O. AlhammadiD· 2 shared Catherine Kerr· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

Anthony R. FehrORCID

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3 papers

Recent·Most cited

MicrobiologyJournal of VirologyPeer-reviewedJul 30, 2025

Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle

Joseph J. O’Connor, Anuradha Roy, Reem Khattabi…·Anthony R. Fehr

This paper investigates how mutations in the coronavirus Mac1 protein affect ADP-ribose binding and hydrolysis, revealing distinct roles in viral replication stages.

3 citations

mouseexperimental assay

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MicrobiologyPLoS ONEPeer-reviewedJun 5, 2025

IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.

Catherine M. Kerr, Macie A. Proctor-Roser, Srivatsan Parthasarathy…·Anthony R. Fehr

This study shows that IFN-γ is required for efficient replication of JHMV in mouse brains, despite reduced viral replication in IFN-γ and IFN-γR knockout mice.

DOI 10.1371/journal.pone.0317482

mousebulk RNA-seq

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MicrobiologyJournal of VirologyPeer-reviewedOct 10, 2024

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

Catherine M. Kerr, Jessica J. Pfannenstiel, Yousef M. O. Alhammad…·Anthony R. Fehr

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

19 citationstop 3%

mousehuman

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