CB1R blockade unmasks TRPV1-mediated contextual fear generalization in female, but not male rats
Kylie A. Huckleberry, Roberto Calitri, Anna J. Li, Mackenna Mejdell, Ashna Singh, Vasvi Bhutani, Mikaela A. Laine, Andrei S. Nastase, Maria Morena, Matthew N. Hill, Rebecca M. Shansky
The paper shows that CB1R blockade increases contextual fear generalization in female rats but not males, mediated by TRPV1R, and identifies sex differences in vHip-BLA circuitry.
Neuropsychopharmacology · Jul 17, 2023Peer-reviewedNeuroscience