Matthew N. Hill

This study examines how nicotinic receptor antagonists affect nicotine and THC self-administration in rats, showing differential effects based on drug availability and receptor subtype.

This study shows that endocannabinoid signaling via CB1r mediates metabolic dysfunction caused by circadian desynchronization, with the liver playing a key role.

This study shows that JZL184 improves motor learning and striatal plasticity in YAC128 HD mice by increasing 2-AG levels, suggesting endocannabinoid modulation as a potential therapeutic target for HD.

The paper identifies endocannabinoid and neuroplasticity-related changes in a rat PTSD model that distinguish susceptible from resilient individuals.

This study examines the effects of prenatal THC vapor exposure on adult rodent bodyweight, adiposity, and glucose metabolism under different dietary conditions, revealing sex- and diet-dependent impacts.

The paper shows that CB1R blockade increases contextual fear generalization in female rats but not males, mediated by TRPV1R, and identifies sex differences in vHip-BLA circuitry.

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

The paper shows that disrupting tonic endocannabinoid signaling increases HPA axis activation by enhancing CRH neuron activity in the PVN, leading to stress-like behaviors and elevated corticosterone.

This study compares THC and metabolite pharmacokinetics in rats after inhalation vs. injection, finding route-specific differences in brain and blood levels and hypothermic responses.

This study examines chronic THC vapor inhalation's effects on pain and vlPAG neuronal function in rats, finding sex-specific rescue of thermal hyperalgesia and cell type-specific modifications in neuronal properties.

This study shows that vaporized THC-rich cannabis extracts reinforce behavior and increase drug-seeking in rats, supporting their use as a preclinical model for cannabis research.

This study shows that postsynaptic pannexin-1 regulates glutamate release and network excitability by facilitating anandamide clearance and modulating TRPV1 activity.