Anna J. Li

The paper introduces Neuropixels Opto probes that combine high-resolution electrophysiology with optogenetics for spatially addressable neuronal manipulation and recording.

The paper investigates trial-to-trial variability in visual cortex spike counts and finds that global cortical activity explains more variability than behavioral factors.

This paper develops a system to simultaneously record and manipulate mesoscopic cortical activity in awake mice, enabling study of its effects on behavior and subcortical activity.

The paper shows optogenetic input to mouse V1 excitatory neurons creates salt-and-pepper patterns of excitation and suppression, with responses not strongly predicted by direct input.

The paper shows that CB1R blockade increases contextual fear generalization in female rats but not males, mediated by TRPV1R, and identifies sex differences in vHip-BLA circuitry.

The paper shows that mice learning to use novel optogenetic activity patterns in V1 experience amplified neural responses, suggesting cortical plasticity improves behavioral performance.

The paper introduces a bicistronic AAV vector that co-expresses GCaMP8s and stChrimsonR in mice, enabling stable and robust two-photon holographic stimulation and imaging of cortical neurons.