CD11c+ Tbet+ B cells constrain obesity- and vaccination-induced germinal center B cells and T helper cells
Carlo Vanz, Benjamin T. Enslow, Emma Collins, Madilyn Dominguez-Lowry, Nathaniel Steven Liendo, Elizabeth A. Dudley, Elizabeth A. Leadbetter
The paper shows that Tbet+ B cells in obesity suppress germinal center B and T helper cells, contributing to immune suppression and metabolic disease.
bioRxiv · Sep 1, 2025 · PreprintImmunology