Low-temperature HILIC provides enhanced separations and stability for LC-MS-based metabolomics
Y Q Liu, Madison L. Jastrab, Michael J. Xiao, Miriam Lisci, Bindu Y. Srinivasu, Taysir K. Bader, Alexis A. Jourdain, Thomas E. Wales, Owen S. Skinner
The paper introduces a low-temperature zwitterionic HILIC method for LC-MS metabolomics, showing improved peak shapes, resolution, and retention time stability compared to standard methods.
Journal of Proteome Research · May 28, 2026Peer-reviewedBioinformatics