Thomas E. Wales

This study identifies how LRRC58 senses cysteine through structural changes that regulate CDO1 binding and cysteine homeostasis.

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

The paper investigates the thermodynamic effects of the Y220C TP53 mutation on Zn2+-binding and shows that Rezatapopt restores Zn2+-affinity through two pathways.

The paper investigates how mutations in charged residues of E. coli β clamp affect its DNA binding and sliding rates.

This study identifies small molecules that stabilize diverse amyloidogenic immunoglobulin light chains by reducing conformational dynamics and proteolysis.

This study investigates how magnesium regulates KRAS conformational dynamics and nucleotide exchange using HDX-MS and functional assays, revealing Mg2+ as a critical structural stabilizer.

The paper introduces a low-temperature zwitterionic HILIC method for LC-MS metabolomics, showing improved peak shapes, resolution, and retention time stability compared to standard methods.

This paper identifies a druggable redox switch on SHP1 that controls macrophage inflammation by developing a covalent agonist targeting a specific cysteine residue.

This study investigates how KIF7, a non-motile kinesin, uses conserved kinesin principles to function as a scaffold in Hedgehog signaling by regulating GLI transcription factors.

This study compares the conformational dynamics of native SARS-CoV-2 Spike protein in virus-like particles to recombinant Spike, finding reduced dynamics in VLP S and implications for epitope display.

This study identifies PDA1 as an SH3-binding allosteric modulator that stabilizes Hck conformation, potentially enhancing combination therapy with ATP-site inhibitors.

This study examines how different BTK inhibitors affect BTK conformation and explains resistance mutation patterns in CLL patients.