Owen S. Skinner

The paper introduces a low-temperature zwitterionic HILIC method for LC-MS metabolomics, showing improved peak shapes, resolution, and retention time stability compared to standard methods.

This paper identifies 4,5-dihydroxyhexanoic acid as a biomarker for mitochondrial disease severity and links it to GABA metabolism.

The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.

The paper shows that metabolic rates influence developmental speed in mouse and human embryos, with mouse cells having higher metabolic rates and faster segmentation clock periods.