Bindu Y. Srinivasu

This study identifies small molecules that stabilize diverse amyloidogenic immunoglobulin light chains by reducing conformational dynamics and proteolysis.

This study investigates how magnesium regulates KRAS conformational dynamics and nucleotide exchange using HDX-MS and functional assays, revealing Mg2+ as a critical structural stabilizer.

The paper introduces a low-temperature zwitterionic HILIC method for LC-MS metabolomics, showing improved peak shapes, resolution, and retention time stability compared to standard methods.

This study investigates how KIF7, a non-motile kinesin, uses conserved kinesin principles to function as a scaffold in Hedgehog signaling by regulating GLI transcription factors.

This study compares the conformational dynamics of native SARS-CoV-2 Spike protein in virus-like particles to recombinant Spike, finding reduced dynamics in VLP S and implications for epitope display.

The paper introduces PyHDX, a tool for analyzing HDX-MS data to compute residue-level Gibbs free energy across protein conditions and homologues.

The paper investigates the structural dynamics of SctV, a component of the Type III translocase export gate in E. coli, revealing its conformational changes and interactions with chaperones and ATPase.