Control of antigen presentation on MHC-I by a bacterial secretion system
Owen K. Leddy, Rachel A. McGinn, Benjamin L. Allsup, Madison Leone, Penny Timms, Matías Gutiérrez-González, Ahmed S. Fahad, Ryan Milligan, Wilfredo F. García-Beltrán, Brandon J. DeKosky, Forest M. White, Bryan D. Bryson
The paper shows that Mycobacterium tuberculosis uses its ESX-1 secretion system to present antigens on MHC-I, bypassing host pathways like autophagy.
bioRxiv · Nov 19, 2025 · PreprintImmunology