Rachel A. McGinn

Targeting fibroblast activation suppresses chemotherapy-induced pro-invasive remodeling of the extracellular matrix

This study shows that chemotherapy activates fibroblasts in TNBC, promoting pro-invasive ECM production, and that nintedanib can suppress this effect.

Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species

This study compares the metabolic states of Mycobacterium tuberculosis in human and mouse macrophages, revealing species-specific lipid metabolism and identifying a barrier to lipid access in human macrophages.

Control of antigen presentation on MHC-I by a bacterial secretion system

The paper shows that Mycobacterium tuberculosis uses its ESX-1 secretion system to present antigens on MHC-I, bypassing host pathways like autophagy.

Systems-level characterization of EGFR kinase inhibitors reveals heterogeneous effects on Mtb-macrophage interactions

This study examines the effects of EGFR kinase inhibitors on Mtb-macrophage interactions, finding heterogeneous outcomes and both direct and host-dependent mechanisms of action.