Author

Wilfredo F. García-Beltrán

Harvard UniversityORCID 0000-0002-7109-0504Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Ahmed S. FahadiD· 1 shared Angelique HölzemeriD· 1 shared Anna P. McLean· 1 shared Benjamin L. AllsupiD· 1 shared Blandine MoneliD· 1 shared Brandon J. DeKoskyiD· 1 shared Bruce D. WalkeriD· 1 shared Bryan D. BrysoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperImmunology

Ahmed S. FahadORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microglia

Friederike Reinsberg, Katharina Schiering, Malte G Lingstaedt, Leonore Mensching, Maisha Adiba, Tom V Kraus, Jan Broder Engler, Imke Liebold, Lidia Bosurgi, Sebastian Schloer, Marcus A. Altfeld, Manuel Alexander Friese, Susanne Krasemann, Ulrike C. Lange, Wilfredo F. García-Beltrán, Angelique Hölzemer

This study shows HIV-1 enhances cell-to-cell transmission from infected CD4+ T cells to microglia by altering surface signals and increasing phagocytosis.

bioRxiv · May 11, 2026 · PreprintImmunology

Control of antigen presentation on MHC-I by a bacterial secretion system

Owen K. Leddy, Rachel A. McGinn, Benjamin L. Allsup, Madison Leone, Penny Timms, Matías Gutiérrez-González, Ahmed S. Fahad, Ryan Milligan, Wilfredo F. García-Beltrán, Brandon J. DeKosky, Forest M. White, Bryan D. Bryson

The paper shows that Mycobacterium tuberculosis uses its ESX-1 secretion system to present antigens on MHC-I, bypassing host pathways like autophagy.

bioRxiv · Nov 19, 2025 · PreprintImmunology

SLAMF6 enables efficient attachment, synapse formation, and killing of HIV-1-infected CD4+ T cells by virus-specific CD8+ T cells

Blandine Monel, Pedro A. Lamothe, James Meyo, Anna P. McLean, Raymond Quiñones‐Alvarado, Mélanie Laporte, Julie Boucau, Bruce D. Walker, Daniel G. Kavanagh, Wilfredo F. García-Beltrán, Yovana Pacheco

This study shows that SLAMF6 is essential for CD8+ T cells to form synapses and kill HIV-1-infected CD4+ T cells, as blocking SLAMF6 reduces conjugate formation and cytotoxicity.

bioRxiv · Jan 20, 2025 · PreprintImmunology