Potential of HLA-E-targeting diabodies to induce lysis of HIV-1-infected cells by CD8+ T cells
Srona Sengupta, Niklas Bachmann, Josephine Zhang, Jacqueline Douglass, Nathan L. Board, Fengting Wu, Milica Moskovljevic, Sarah R. DiNapoli, P. Aitana Azurmendi, Yasmine Tabdili, Madison Reed, Jeanna Yu, Emily Han-Chung Hsiue, Bailey Kim, Hui Zhang, , Robert F. Siliciano
This paper demonstrates that HLA-E-targeting diabodies can induce CD8+ T cell-mediated lysis of HIV-1-infected cells, bypassing limitations of classical MHC class I antigens.
bioRxiv · Apr 29, 2026 · PreprintMicrobiology