Author

Jacqueline Douglass

Howard Hughes Medical InstituteORCID 0000-0002-9113-7090Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Emily Han-Chung HsiueiD· 2 shared Sarah R. DiNapoliiD· 2 shared Alexander H. PearlmaniD· 1 shared Bailey Kim· 1 shared Bert VogelsteiniD· 1 shared Brian J. MogiD· 1 shared Chetan BettegowdaiD· 1 shared Drew M. PardolliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

Emily Han-Chung HsiueORCID

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2 papers

Recent·Most cited

Potential of HLA-E-targeting diabodies to induce lysis of HIV-1-infected cells by CD8+ T cells

Srona Sengupta, Niklas Bachmann, Josephine Zhang, Jacqueline Douglass, Nathan L. Board, Fengting Wu, Milica Moskovljevic, Sarah R. DiNapoli, P. Aitana Azurmendi, Yasmine Tabdili, Madison Reed, Jeanna Yu, Emily Han-Chung Hsiue, Bailey Kim, Hui Zhang, , Robert F. Siliciano

This paper demonstrates that HLA-E-targeting diabodies can induce CD8+ T cell-mediated lysis of HIV-1-infected cells, bypassing limitations of classical MHC class I antigens.

bioRxiv · Apr 29, 2026 · PreprintMicrobiology

Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells

Alexander H. Pearlman, Brian J. Mog, Michael S. Hwang, Jordina Rincón-Torroella, Sarah R. DiNapoli, Suman Paul, Jacqueline Douglass, Emily Han-Chung Hsiue, Stephanie A. Glavaris, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Chetan Bettegowda, Shibin Zhou, Bert Vogelstein, Maximilian F. Konig

This paper engineers effector cells resistant to bacterial toxins to deliver immunotoxins specifically to cancer cells and introduces a platform for therapeutic cell type development.

bioRxiv · Dec 11, 2025 · PreprintMolecular Biology