Sarah R. DiNapoli

Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

The paper designs an AND-gated CAR T cell receptor called MANTIS that uses extracellular size differences to spatially regulate signaling for precise antigen recognition.

Potential of HLA-E-targeting diabodies to induce lysis of HIV-1-infected cells by CD8+ T cells

This paper demonstrates that HLA-E-targeting diabodies can induce CD8+ T cell-mediated lysis of HIV-1-infected cells, bypassing limitations of classical MHC class I antigens.

Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells

This paper engineers effector cells resistant to bacterial toxins to deliver immunotoxins specifically to cancer cells and introduces a platform for therapeutic cell type development.

Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells

This study develops anti-9G4 CAR-T and TCR-T cells to selectively target autoreactive B cells in SLE, reducing immunosuppression and cytokine toxicity.