WNK-Dependent Phosphorylation of Gephyrin Tunes GABAA Receptors at Inhibitory Synapses and Modulates Anxiety Behavior
Zaha Merlaud, Célia Delhaye, Margarida Nabais, Erwan Pol, Tânia Lima, Yann Verdier, Zahra Imani, Marion Russeau, Nalia Samba, Maelys Tostain, Juliette Gouhier, Romane Rahir, Joëlle Vinh, Corentin Le Magueresse, Marika Nosten‐Bertrand, Sabine Lévi
This study identifies a WNK-dependent phosphorylation mechanism that regulates GABAAR stability and synaptic function, leading to altered anxiety behavior in mice.
Proceedings of the National Academy of Sciences · Aug 25, 2026Peer-reviewedNeuroscience