Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy
Magali Humbert, Kristina Seiler, Severin Mosimann, Vreni Rentsch, Sharon L McKenna, Mario P Tschan
This study shows that reducing FASN expression enhances AML cells' response to differentiation therapy by promoting lysosomal biogenesis and TFEB activation.
bioRxiv · Jan 29, 2020Cancer Biology