Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease.
Yann Grobs, Sarah-Eve S Lemay, Manon Mougin, Charlie Théberge, Magalie Boucher, Sandra Breuils‐Bonnet, Sandra Martineau, Alice Bourgeois, Andréanne Pelletier, Maud Fillon, Jean Perron, François Potus, Steeve Provencher, Olivier Boucherat, Sébastien Bonnet
This study identifies hypusine signaling as a driver of vascular smooth muscle cell proliferation in restenosis and shows that inhibiting DHPS reduces neointimal hyperplasia in preclinical models and human tissue.
Arteriosclerosis Thrombosis and Vascular Biology · Jul 2, 2026Peer-reviewedPathology