Sandra Martineau

This study identifies hypusine signaling as a driver of vascular smooth muscle cell proliferation in restenosis and shows that inhibiting DHPS reduces neointimal hyperplasia in preclinical models and human tissue.

The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.

This study identifies ATP-citrate lyase as a driver of vascular remodeling in pulmonary hypertension and coronary artery disease, showing its inhibition can reverse pathological changes.

This study shows that targeting Snai1 in the right ventricle rescues pulmonary hypertension-induced failure by reducing EndMT, fibrosis, and FMT through a LOXL2-dependent mechanism.