Shedding light on left hippocampal mGlu5 in Alzheimer's disease
Charleine Zussy, Magalie Mathias, Mathieu Vitalis, Xavier Gómez‐Santacana, Cyril Goudet, Catherine M. Desrumaux, Amadeu Llebaria, Laurent Givalois
The paper shows that mGlu5 expression is asymmetrically distributed in the hippocampus of wild-type mice, and this asymmetry is lost in AD model mice, with left-specific inhibition of mGlu5 restoring memory and reversing pathology.
bioRxiv · Oct 3, 2025 · PreprintNeuroscience