Catherine M. Desrumaux

The paper shows that mGlu5 expression is asymmetrically distributed in the hippocampus of wild-type mice, and this asymmetry is lost in AD model mice, with left-specific inhibition of mGlu5 restoring memory and reversing pathology.

This study shows that microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer's disease by enhancing lysosomal activity and reducing Aβ clearance.