Arginine methyltransferase signalling is hyperactive in conditions of neuromuscular junction instability and muscle atrophy
Andrew I. Mikhail, Sean Y. Ng, Magda A. Lesinski, Stephanie R. Mattina, Derek William Stouth, Rozhin Raziee, Changhyun Lim, Gautham Vasam, Keir J. Menzies, Stuart M. Phillips, Mark Andrew Tarnopolsky, Vladimir Ljubicic
This study shows that CARM1 activity increases in neuromuscular junction instability and muscle atrophy in mice and humans, correlating with NMJ dysfunction and muscle health decline.
bioRxiv · Sep 15, 2026 · PreprintPhysiology