Stuart M. Phillips

Arginine methyltransferase signalling is hyperactive in conditions of neuromuscular junction instability and muscle atrophy

This study shows that CARM1 activity increases in neuromuscular junction instability and muscle atrophy in mice and humans, correlating with NMJ dysfunction and muscle health decline.

Plasma metabolite responses to an oral protein tolerance test differ between young and sarcopenic participants and suggest altered anabolic sensitivity

This study uses an oral protein tolerance test combined with metabolomics to show that sarcopenic older adults have slower postprandial decline in essential amino acids compared to young controls, suggesting altered anabolic sensitivity.

Dynamic proteomic profiling reveals protein-specific regulation of synthesis rates underpinning the divergent adaptation of human muscle to endurance and resistance training

This study identifies protein-specific synthesis rate changes in human muscle under endurance and resistance training, revealing mode-specific adaptations in subcellular protein subsets.

A network-based atlas of human skeletal muscle aging

This paper develops a network-based atlas of human skeletal muscle aging using transcriptomic data from 1,675 biopsies and multiple single-cell technologies, revealing gene modules and interactions associated with aging and load status.

Skeletal muscle mitochondrial responses to a single bout and six weeks of high load versus high volume resistance training in previously trained men

This study compares mitochondrial mRNA and protein responses to high-load and high-volume resistance training in trained men, finding no differences between the two training paradigms.

Global Skeletal Muscle Metabolomics Reveals Mechanisms Behind Higher Response to Resistance Training in Older Adults

The paper identifies metabolic pathways disrupted in low responders to resistance training in older adults using metabolomics.

Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling

The paper identifies ncRNA genes regulated during skeletal muscle hypertrophy in 144 individuals using transcriptomic analysis and network modelling.