Disruption of a six-nucleotide miRNA motif improves PKD1 dosage and ameliorates polycystic kidney disease
Ronak Lakhia, Chunzi Song, Laurence Michael Biggers, Maggie Zumwalt, Jesus Alvarez, Arvind Somasundarum, Harini Ramalingam, Patricia Cobo-Stark, Vishal Patel
This paper identifies a six-nucleotide miRNA motif that represses PKD1 and shows that disrupting it improves PKD1 dosage and reduces cyst growth in ADPKD models.
Nucleic Acids Research · Jan 6, 2026Peer-reviewedGenetics