Ashwin Somasundaram

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

This paper identifies a six-nucleotide miRNA motif that represses PKD1 and shows that disrupting it improves PKD1 dosage and reduces cyst growth in ADPKD models.

SPaRTAN links cell-surface receptors to transcription factors using CITE-seq data and cis-regulatory information, revealing novel receptor-TF relationships in immune and tumor cells.