Astrocytic L-lactate signaling in the anterior cingulate cortex is essential for schema memory and neuronal mitochondrial biogenesis
Mastura Akter, Mahadi Hasan, Aruna Surendran Ramkrishnan, Xianlin Zheng, Zafar Iqbal, Zhongqi Fu, Zhuogui Lei, Anwarul Karim, Ying Li
This study shows that astrocytic Gi signaling in the ACC reduces L-lactate levels, impairing schema memory and neuronal mitochondrial biogenesis in rats, with L-lactate rescue reversing these effects.
eLife · Nov 2, 2023Peer-reviewedNeuroscience