Xianlin Zheng

Visualising sub-second dynamics of nanoparticle extravasation in vivo

This study uses upconversion nanoparticles and real-time imaging to visualize vascular permeability changes in zebrafish, revealing distinct transcellular and paracellular transport mechanisms and demonstrating enhanced BBB penetration with functionalized nanoparticles.

Astrocytic L-lactate signaling in the anterior cingulate cortex is essential for schema memory and neuronal mitochondrial biogenesis

This study shows that astrocytic Gi signaling in the ACC reduces L-lactate levels, impairing schema memory and neuronal mitochondrial biogenesis in rats, with L-lactate rescue reversing these effects.