Reduced enteric Bdnf expression and TrkB-dependent regulation of Vip in a Mecp2-null mouse model of Rett syndrome-associated gastrointestinal dysmotility
Srinivas N. Puttapaka, Israel Abebe Admasu, Ainsleigh Scott, Gamze Sönmez, Philippa Seika, Mahalakshmi Rajkumar, Xavier Valencia, Alan Consorti, Su Min Hong, Jared Slosberg, Michela Fagiolini, Subhash Kulkarni
This study identifies reduced enteric Bdnf and altered VIPergic signaling as key mechanisms of GI dysmotility in a Mecp2-null mouse model of Rett syndrome.
bioRxiv · Apr 15, 2026 · PreprintNeuroscience